Phenomapping Heart Failure with Preserved Ejection Fraction Using Machine Learning Cluster Analysis

Heart failure with Preserved Ejection Fraction; learning from failure

Phenomapping for novel classification of heart failure with preserved ejection fraction.

BACKGROUND Heart failure with preserved ejection fraction (HFpEF) is a heterogeneous clinical syndrome in need of improved phenotypic classification. We sought to evaluate whether unbiased clustering analysis using dense phenotypic data (phenomapping) could identify phenotypically distinct HFpEF categories. METHODS AND RESULTS We prospectively studied 397 patients with HFpEF and performed det...

Phenomapping for Novel Classification of Heart Failure with Preserved Ejection Fraction Running title :

Address for Correspondence: Sanjiv J. Shah, MD, FAHA, FACC Rahul C. Deo, MD, PhD Division of Cardiology, Dept of Medicine Division of Cardiology, Dept of Medicine Feinberg Cardiovascular Research Institute Cardiovascular Research Institute Northwestern Univ Feinberg School of Medicine University of California, San Francisco 676 N. St. Clair St., Suite 600 555 Mission Bay Boulevard South Chicago...

Heart Failure With Preserved Ejection Fraction

The Journal of the American Osteopathic Association July 2015 | Vol 115 | No. 7 432 From Henry Ford Wyandotte Downriver Cardiology in Brownstown, Michigan (Dr Rogers); West Suburban Medical Center in Oak Park, Illinois (Dr Gundala); Oakwood Southshore Medical Center in Trenton, Michigan (Dr Ramos); and Elmhurst Memorial Hospital in Illinois (Dr Serajian). Drs Gundala and Ramos are in their thir...

Heart Failure With Preserved Ejection Fraction

Symptomatic heart failure, despite preserved left ventricular (LV) ejection fraction, is a well-recognized phenomenon. This manifestation of diastolic dysfunction is associated with increased morbidity and mortality and can be attributed to a variety of pathogeneses, including diabetes mellitus, hypertension, infiltrative processes, and obesity. Unlike in systolic heart failure, where LV ejecti...